The pharmacokinetics of ampicillin and sulbactam in pediatric patients receiving ampicillin and sulbactam for injection are similar to those observed in adults. Safety and efficacy for the treatment of intraabdominal infections have not been established in patients younger than 18 years. This has been observed to a greater extent with tobramycin and gentamicin, while amikacin has shown greater stability against inactivation.
The pH of the solutions is between 8.
Diabetic foot infection, moderate to severe: IV: 3 g every 6 hours Harkless 2005. It has been reported to occur in 16% of patients receiving intramuscular injections, and 3% of patients receiving intravenous injections.
NextIt is active against a wide range of bacterial groups, including , , and.
Its chemical formula is C 8 H 10 NNaO 5 S with a molecular weight of 255. Rx Only To reduce the development of drug-resistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection and other antibacterial drugs, ampicillin and sulbactam for injection should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. Reduced clearance has been seen in both pediatric and post-operative patients.
NextUses: For the treatment of intraabdominal infections due to susceptible, beta-lactamase-producing strains of E coli, Klebsiella species including K pneumoniae , Bacteroides species including B fragilis , Enterobacter species Usual Adult Dose for Bacterial Infection 1.
It is formulated in a 2:1 ratio of ampicillin:sulbactam. The mean serum half-life of both drugs is approximately 1 hour in healthy volunteers.
NextAvoid combination BCG Vaccine Immunization : Antibiotics may diminish the therapeutic effect of BCG Vaccine Immunization.
Accessed November 21, 2014. Not all possible drug interactions are listed here. This medicine is usually given every 6 hours for 14 days.
NextTalk to your doctor if you have questions.
Performance Standards for Antimicrobial Disk Diffusion Susceptibility Tests; Approved Standard — 11th ed. The structural formula is: Sulbactam sodium is a derivative of the basic penicillin nucleus.
NextDuration depends on extent and severity of infection as well as response to therapy; may switch to oral treatment when clinically improved.
Approximately 75 to 85% of both ampicillin and sulbactam are excreted unchanged in the urine during the first 8 hours after administration of ampicillin and sulbactam for injection to individuals with normal renal function. After mixing ampicillin and sulbactam, you will need to use it within a certain number of hours. Storage Prior to reconstitution, store at 20°C to 25°C 68°F to 77°F.
NextProtein Binding Sulbactam: 38% Use: Labeled Indications Bacterial infections: Treatment of skin and skin structure, intra-abdominal, and gynecological infections caused by susceptible bacteria; spectrum is that of ampicillin plus organisms producing beta-lactamases such as Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Klebsiella, Acinetobacter, Enterobacter, and anaerobes.